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TOPIC: Article in Journal Health Market in October

Article in Journal Health Market in October 28 Sep 2014 11:14 #2321

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CATHERINE ROŻKO / MARKET HEALTH | 24-09-2014 6:14
Wounds heal burns "cocktails" of stem cells. Results comparable to USA
The country mortality burned in the past few years has dropped from 22 per cent. to 5.2 per cent. This results similar to those achieved in American clinics Navy, which are well developed in this area. Receive them by specialists in the Burns Centre Siemianowice using, among others, Allogeneic stem cell transplants. This is the world premier league.
- Learned to save heavily burned and people with severe injuries, shock pooparzeniowym fight. Everything must be done to these patients can live normally in society - said in an interview with Market Health Assoc. Marek Kawecki, general surgery specialist, deputy director. Medical Burns Centre in Siemianowice.
It describes the progress that has been made in the treatment of burns and wounds, among others, due to the possibility of preparing a Siemianowicka "oparzeniówce" preparations of fat stem cells of the patient and the culture of skin cells for transplantation.
Market Health: One of the modern methods used in the Burns Centre is the use of stem cells in the treatment of burns and chronic wounds. What are the advantages of this therapy?
Doc. Marek Kawecki: - The use of stem cells generate the healing process. Studies have shown that transplantation of stem cells from adipose tissue through as quickly as possible sybstytutu administration of stem cells and regenerative ADRCs (Adipose Derived Regenerative Cells) accelerates healing, stimulates epidermal skin granulation tissue and angiogenesis.
We use the stem cells derived from autologous adipose tissue or fat tissue of the patient. Importantly, the whole procedure adipose tissue, isolation of the cell preparation and the application is closed in one operating cycle. We use device for obtaining stem cells and regeneration of the patient's own adipose tissue Celution 800 / CRS company Cytori Therapeutics.
The method of obtaining stem cells from adipose tissue is subject to the adipose tissue by liposuction, enzymatic digestion, centrifugation and washing several times, and then washing away the fat cells. In this way, the stem cells obtained which is ready for use.
- In which patients could use this procedure?
- seriously burned patients as well as patients with chronic wounds, in which there was a significant loss in their tissues. We used stem cells derived from adipose tissue, eg. A man, in whom there has been a substantial loss of skin and muscle leg. The procedure is used when we want a renewal of tissues in a functional sense.
- Are there any restrictions on the use of this therapy?
- The limitation may be, for example. lack of adipose tissue. Usually, we have a problem with obesity population, while some patients after trauma or burns has little body fat and is a problem with downloading it. The first step in this process is the suction of fat, then the device processes the formulation to be administered, and must be taken to ensure the volume of adipose tissue by a computer controller initiated work apparatus.
Adipose tissue offers the most advantages. The advantage of body fat compared to other sources of stem cells supported by less invasive method of obtaining the material. In addition, the adipose tissue is 2500 times more stem cells than bone marrow. The fact that there is so much, lets hope that in the sense of a functional complement the loss of tissue. Using the preparation of stem cells derived from adipose tissue are trying to bring about the best possible degree of tissue regeneration.
100 ml of the preparation obtained from the adipose tissue have 400 thousand. stem cells; most of these are progenitor cells, both hematopoietic and epithelial cells, stromal cells of the epithelium. A well-made preparation has all the ingredients.
- In how many patients Burn Treatment Center uses stem cells?
- Until przeszczepiliśmy stem cells 15 people. Among them were patients with hard to heal wounds of the lower leg and the back of the hand, foot, diabetic, third degree burns of the foot and ankle external chest burns, trophic ulceration of the foot, third degree frostbite toes, extensive wound from trauma or scars zmiażdżeniowym pooparzeniowymi of loss soft tissue hip.
The recent history is a special case of a young woman who came to burn in the hip. Necrosis was cut and the resulting substantial loss in adipose tissue, with very deep grooves. Application of stem cells in this region smoothed her the furrows - the patient's skin looks much better now.
- Is the medical community is interested in introducing therapies using stem cells?
- For several years, interest in stem cells increases steadily, because their use is progress and the next step in medicine. We have reduced mortality burned in the past few years, with 22 percent. to 5.2 per cent. achieving results similar to those obtained in American clinics Navy, which are well developed in this area.
We have learned to save heavily burned and heavily offended, fight pooparzeniowym shock, but it is not the end - everything must be done by patients are able to live in the community. Stem cells are one of the ways. We wrote about this a few works. Many times we published our reports on the Polish and international conventions. This procedure is in very good European centers.
- In addition to the use of stem cells in the treatment of wounds przewklekłych CLO use other modern procedures ....
- Yeah. Founded in our Laboratory of Cell Cultures and Tissues in vitro Tissue Bank - the only such unit in Poland in the case of hospitals providing treatment of burns. It gives us great opportunities. To the standards we have implemented a procedure for the treatment of transplantation of autologous keratinocytes and fibroblasts cultured in vitro, and Tissue Bank is continuously deposited allogenic skin, which is obtained during multiorgan downloads.
Allograft in the shortest time since the creation of extensive skin loss guarantees to stabilize the patient's condition and allows you to prepare it for the skin mesh graft or transplant of autologous skin grown in vitro. For many seriously burned patients, it is a life-saving transplant. We grow the skin cells of patients in the hospital. If there are such indications, the patient has established breeding, which is usually after 21 days is qualified for transplantation.
It is based on Breeding Laboratory of Cell and Tissue in vitro Tissue Bank introduced another segment of modern procedures, which is the use of stem cells. Tissue Bank has great professional and appropriate conditions in which adipose formulation can be obtained for transplantation. We also have a trained group of plastic surgeons who are able to get this tissue without complications.
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Article in Journal Health Market in October 28 Sep 2014 18:29 #2322

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DOV , nice article. Further confirmation of ease of access, high ADRC cell count, ease of use, and most importantly, efficacy in a variety of burn and wound indications.

This sort of anecdotal evidence/data is what has been keeping us in this company. I hope management exhibits the urgency required to bring this technology to market quickly before it is superseeded by technological advances that are inevitable.

So many different trials being run worldwide and yet we know nothing. We need to know more about what is going on with all these trials, particularly those that have provided data leading to CE authorisations in the past, eg. Crohns fistula. Also would be nice to know what has happened with ADVANCE data to date , although I guess they may be putting off analysing the data with a view to keeping the trial alive, even if delayed ........... maybe they should partner European acute market to BP and keep USA to themselves. This would provide funding and recognition/validation. Running both chronic and acute heart disease trials concurrently would be huge as it would provide the data required for worldwide rollout of the technology in both indications much sooner ...... with a corresponding benefit to our SP, and patients.
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Article in Journal Health Market in October 29 Sep 2014 08:23 #2323

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The Polish article can be viewed here : Kawecki Article



Actually in the Dreamweaver predecessor of this page (2010/11) I already wrote about this one (the national burns clinic in Poland) - thereto about some publications that were made by scientists at the Hannover University Clinic, which specializes in burns just as their colleagues in Aachen. The studies were published in German.
Both clinics worked with Celution, which should not surprise anybody.

The surprise here really is- why has there not been more adoption and marketing on the application, which is clearly doing some miracle stuff, also with easier cases than the 15 "heavy cases" mentioned in the Kawecki article.

Anyway-

This area in Poland- Silesia- is quite advanced in medical terms. Actually ADVANCE had only 4 clinics that enrolled- three of them were in Poland- thereof 2 in Krakow.
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Board moderator and Site-owner. I still regret the day I started analysing the prospects of MacroPore (now Cytori) back in 2004- a left-over from the tech-bubble at that time from the century change in my portfolio- and became addicted to Cytori´s fat cell technology. :cry:

Article in Journal Health Market in October 29 Sep 2014 08:49 #2324

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***The surprise here really is- why has there not been more adoption and marketing on the application, which is clearly doing some miracle stuff, also with easier cases than the 15 "heavy cases" mentioned in the Kawecki article.***

fas, we've been wondering for so long why there is no adoption for the many applications that appear to be "no brainers". The near miracle results are there for the taking, but yet no one stepping up to the plate. We should have been seeing results to the bottom line from this burn indication years ago, at the very least, for compassionate use. Very unfortunate, for all parties.

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