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TOPIC: ATHX looks sick

ATHX looks sick 15 Apr 2015 10:06 #4213

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And this Sunday results are released.... not good FOR NOW, but must turn around today!!!

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ATHX looks sick 15 Apr 2015 10:27 #4214

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Profit taking before the preliminary data is announced. They need some good outcomes with stroke. It could be a home run. The colitis fiasco was a major setback. They need this to be positive. Good luck to them. Helping stroke victims is a great cause.

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ATHX looks sick 15 Apr 2015 11:10 #4216

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I do not follow ATHX very much at all, besides what folks post on this board.

But surely - for Aga- I presume the stroke data is presented at some medical conference of the equivalent of AHA for stroke right?

And presented by the PI?

Since there surely are a lot of folks holding stakes in both ATHX and CYTX- all the best and may MultiStem be with you. :yep:

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Board moderator and Site-owner. I still regret the day I started analysing the prospects of MacroPore (now Cytori) back in 2004- a left-over from the tech-bubble at that time from the century change in my portfolio- and became addicted to Cytori´s fat cell technology. :cry:

ATHX looks sick 15 Apr 2015 13:55 #4218

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ESOC European Stroke Organization Conference on Sunday.

I am not sure yet, Thursday/Friday will be when they show their hand... But for a few days, it looked like a yellow flag, and today a red one...

Will know more by tomorrow this time, but if the results are bad then watch out below... The amazing part is that if the results are bad, then why would you take it that conference? UNLESS it is Gil's way of milking that cow dry... Worse case scenario..

It could be, "we don't know and we need to do more cells/times of treatment"?

Technically, they could trade below 2.50 and still be in the uptrend... so, maybe shaking the tree.

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ATHX looks sick 15 Apr 2015 18:44 #4219

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It would be hard to believe ATHX may fail in the multistem trial in stroke recovery (treatment vs placebo, looking for a difference). This study is more conservative in comparison with the ulcerative colitis trial. But, still the stroke study is a brave one with very little/or no prior human data.

But, one would never know the outcome till this weekend.

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ATHX looks sick 16 Apr 2015 11:07 #4227

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Seems as though a lot of people are very nervous. It is a gigantic breakthrough if it can be proved effective. Ischemic stroke is a devastating condition anything that can mitigate the effects would be a great thing for many many people. It would be a catalyst for regenerative medicine in general.

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ATHX looks sick 16 Apr 2015 14:07 #4232

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The beating up of the stock is rather concerning... whatever way you look at it. :whistle:

WST, care to give your opinion on whats going on?

AF is surely preparing on the sidelines here too, I suppose. :whistle:

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Board moderator and Site-owner. I still regret the day I started analysing the prospects of MacroPore (now Cytori) back in 2004- a left-over from the tech-bubble at that time from the century change in my portfolio- and became addicted to Cytori´s fat cell technology. :cry:

ATHX looks sick 16 Apr 2015 15:07 #4233

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the play of the unknown. :bye:

that is a good personal training - have i a opinion .. am i right ???

regards holdi

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holdi

ATHX looks sick 16 Apr 2015 15:18 #4235

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I have no idea what to think about the last two day's of trading. All I can say is that the circumstantial evidence combined with the pre-clinical data and research done in humans regarding the role of the spleen in stroke still leave me optimistic for Sunday. Someone on the MB said they called the company and all of senior management were en route to Glasgow for the presentation. Would they ALL be going for their own funeral? No explanation for stock price decline but I still think this will work out and Chugai partnership will move forward. We will KNOW soon enough.
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ATHX looks sick 16 Apr 2015 15:21 #4236

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Sure looks like a buying opportunity if you have the testicles!
:grin:

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ATHX looks sick 16 Apr 2015 16:11 #4237

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WST, it is so awesome to be so popular... you say you don't know what the heck is going on and you get three thank you... someone on YMB claims this 10 million shares and 30% drop was based on a rumor and people call it a buying opportunity...

So awesome to be you :cool:

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ATHX looks sick 16 Apr 2015 17:09 #4238

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If the treatment arm and placebo are about the same, the stock will drop sharply, but I think the company will still survive.

It the study results are good , the stock price may still drop, because the data will always not good enough and there will still be questions. However, if the PPS drops off the cliff before good results, I think the stock price will rebound sharply.

ATHX looks risky right now. One should not try to read tea leaves for clues.

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ATHX looks sick 16 Apr 2015 18:48 #4240

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There's only one person on these boards that I can think of that would make a comment like that. Chuck?

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ATHX looks sick 17 Apr 2015 06:19 #4243

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CLEVELAND, April 17, 2015 (GLOBE NEWSWIRE) -- Athersys, Inc. (ATHX) today announced interim results from its exploratory Phase 2 clinical study of the intravenous administration of MultiStem® cell therapy to treat patients who have suffered an ischemic stroke. The study results demonstrate favorable safety and tolerability for MultiStem, consistent with prior studies. With respect to the primary and secondary endpoints, the cell therapy did not show a difference at 90 days compared to placebo. However, MultiStem treatment was associated with lower rates of mortality and life threatening adverse events (AEs), infections and pulmonary events. Furthermore, post-hoc analysis shows that patients who received MultiStem treatment earlier in the treatment window had more robust recovery rates in comparison to placebo and relative to patients who received later MultiStem treatment.

Dr. David Hess, lead clinical investigator in the study, stroke specialist and Chairman of the Department of Neurology at the Medical College of Georgia at Georgia Regents University, will present the summary results at the European Stroke Organization conference on Sunday, April 19th at 8:50 AM in Glasgow, Scotland, United Kingdom.

Data highlights from the 90-day interim analysis include:

MultiStem cell therapy demonstrated favorable tolerability and safety profile through the evaluation date, which was at least 90 days for all patients;
Patients who received intravenous administration of MultiStem did not show a significant difference from placebo-treated patients for the primary endpoint (Global Stroke Recovery Assessment) and the related secondary endpoints which were defined as the proportion of patients achieving a modified Rankin Scale (mRS) value of 0-2, improvement in the NIH Stroke Scale (NIHSS) by e 75% and achieving Barthel Index (BI) e 95 at day 90, however;
Among all subjects who received MultiStem treatment, 15.4% of patients achieved an Excellent Outcome, defined clinically as attaining mRS 0-1, NIHSS 0-1 and BI e95, compared to 6.6% of patients that received placebo, (p=0.10);
As described in the table below, patients who received MultiStem treatment earlier in the treatment window (24-36 hours post-stroke) exhibited more favorable recovery on the primary and key secondary endpoints than patients who received placebo or patients who received MultiStem treatment later (e.g. Excellent Outcome, p = 0.03), and this treatment effect was even more pronounced the earlier the MultiStem administration within the 24-36 hour timeframe;
A higher proportion of patients who received treatment with MultiStem achieved a good clinical outcome by day 7 after treatment, defined as achieving mRS 0-2, which was 12.9% for patients receiving MultiStem, compared to 5.2% of patients who received placebo, and a similar pattern was seen for improvement in NIHSS e 75%, which was achieved by 10.2% of MultiStem treated patients vs. 3.9% of patients who were treated with placebo;
Mortality was lower among patients who received treatment with MultiStem in comparison with placebo. There were 9 subject deaths (14.8%) among those receiving treatment with placebo, and only 4 patient deaths (6.2%) among patients receiving treatment with MultiStem;
The MultiStem treatment group had a lower rate of life threatening adverse events and death (p=0.04), and also exhibited lower rates of pulmonary events (p=0.08) and infections. The MultiStem treated group also had a significantly lower level of circulating CD-3+ T-cells at two days following dosing (p<0.01), suggesting a reduction in the inflammatory response post-stroke, consistent with the therapeutic hypothesis.


The market will not like this.. :whistle:
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Board moderator and Site-owner. I still regret the day I started analysing the prospects of MacroPore (now Cytori) back in 2004- a left-over from the tech-bubble at that time from the century change in my portfolio- and became addicted to Cytori´s fat cell technology. :cry:

ATHX looks sick 17 Apr 2015 08:05 #4244

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Wall Street Titan wrote: There's only one person on these boards that I can think of that would make a comment like that. Chuck?


You mean Franshei or me? I am not, BTW.

WST, This is the time for you to write another article. I am not joking either, people value your opinion. Your articles motivated a lot of people to buy, and they need to hear from you. Don't disappear.

This was what I meant, I see the thing diving yet they want to hear from you to say it is going to be OK. People like you can run for president.

I am not being sarcastic at all. Better luck next time, maybe with CYTX...

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ATHX looks sick 17 Apr 2015 08:13 #4246

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Years ago I learned a lesson. ATHX showed the sings when I posted, and I sold after I posted. so my conscious is clear.

When the technical tell you, you'd better listen. At least CYTX should get a boost today from this disaster....

To those who lost money, I am sorry... I wish I was more forceful with my warning.

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ATHX looks sick 17 Apr 2015 08:29 #4247

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Fas, it will be very interesting to see if Chugai can market it with these results? :KO:

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ATHX looks sick 17 Apr 2015 09:03 #4248

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I think it is a buying opp. they took on a big bear in ischemic stroke and IMO the treatment time frame was too far out; however, they did demonstrate some efficacy. Their approach was to treat a catastrophic event via a complex system, ie, many body systems involved, eg, cytokines, interferons, spleen, brain, circulatory system, etc. IMO, we don't know enough yet--body function wise--to be confident of treatment. I do think this trial helped us understand the above better and is another step toward efficacious treatment. GLTA

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ATHX looks sick 17 Apr 2015 10:14 #4249

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WST: Franshei is not Chuck. I think Chuck is long gone. Franshei lives in Chicago, not NYC. He is a former director of clinical r/d at Fujisawa (now Astella) and cofounder of SuperGen. He is a senior citizen, retired in 1998.

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ATHX looks sick 17 Apr 2015 10:30 #4250

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Franshei, I was not referring to you. I was referring to a comment on how many "Thank Yous" a poster got. Seemed kind of weird.

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